FAQs
Combinatorial Chemistry
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What are SynPhase™ Lanterns?
SynPhase Lanterns are discrete, modular and quantized solid supports optimized for the synthesis of small organic compounds. The SynPhase Lanterns offer synthesis characteristics comparable to, or better than, commonly available low-cross-linked polystyrene resins, whilst at the same time delivering the ultimate in handling convenience. There is no need for time-consuming tasks such as weighing and filtering with SynPhase Lanterns. The modular design makes SynPhase Lanterns adaptable to any type of synthesis strategy such as parallel array handling or tagged split and pool techniques. In many ways a SynPhase Lantern can be thought of as a large, stable, polystyrene resin bead.
At the core of SynPhase technology is a mobile surface polymer grafted onto a rigid unreactive base polymer. This provides a solid framework for reliable handling of the solid phase during all stages of synthesis. Our specialized grafting process yields a uniform 50µm polystyrene graft, delivering high performance reaction kinetics with minimal batch-to-batch variations in loading. The unique "Lantern" shape provides maximized surface area, free flow-through of reactants and rapid drainage of wash solutions. - What are the physical dimensions of SynPhase™ Lanterns?
- What is the fundamental difference between SynPhase™ Lanterns and Polystyrene Resins?
- Are there any special storage requirements with SynPhase™ Lanterns?
- What is the typical loading capacity of SynPhase™ Lanterns?
- What linkers are available with SynPhase™ Lanterns?
- How does the performance of SynPhase™ Lanterns compare to polystyrene resins?
- Does polystrene resin chemistry transfer directly to SynPhase™ Lanterns?
- What solvents are compatible with SynPhase™ Lanterns? What are the swelling characteristics of SynPhase™ Lanterns in various solvents?
- What are the recommended volumes and concentrations of reagents for use with SynPhase™ Lanterns?
- What synthesis strategies can be used with SynPhase™ Lanterns?
- Can SynPhase™ Lanterns be used in solution phase applications?
- Is there a SynPhase™ Lantern suitable for hydrophilic applications?
- Can SynPhase™ Lanterns be used in automated synthesizers?
- How does the cost of SynPhase™ Lanterns compare to resin(s)?