FAQs
Combinatorial Chemistry
- What are SynPhase™ Lanterns?
- What are the physical dimensions of SynPhase™ Lanterns?
- What is the fundamental difference between SynPhase™ Lanterns and Polystyrene Resins?
- Are there any special storage requirements with SynPhase™ Lanterns?
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What is the typical loading capacity of SynPhase™ Lanterns?
Loading values typically range from 14-16 µmol for SynPhase L-Series Lanterns and 34-38 µmol for SynPhase D-Series Lanterns. The variation in loading within a particular batch is typically less than 0.6µmol for SynPhase L-Series Lanterns and less than 1.5µmol for SynPhase D-Series Lanterns. Product yields of 7-8mg for SynPhase L-Series Lanterns and 17-19mg for SynPhase D-Series Lanterns can be expected, based upon a compound of 500 MW and a yield of close to 100%.
The batch-to-batch variation in loading of 47 consecutive batches of SynPhase D-Series Lanterns is presented below. The average loading for each batch was determined by quantitative Fmoc analyses on 10 SynPhase D-Series aminomethylated Lanterns, coupled with Fmoc-b-alanine (120mM Fmoc-b-alanine, DIC/HOBt activation).
Batch to batch loading variation in SynPhase Lanterns is typically less than 5% - What linkers are available with SynPhase™ Lanterns?
- How does the performance of SynPhase™ Lanterns compare to polystyrene resins?
- Does polystrene resin chemistry transfer directly to SynPhase™ Lanterns?
- What solvents are compatible with SynPhase™ Lanterns? What are the swelling characteristics of SynPhase™ Lanterns in various solvents?
- What are the recommended volumes and concentrations of reagents for use with SynPhase™ Lanterns?
- What synthesis strategies can be used with SynPhase™ Lanterns?
- Can SynPhase™ Lanterns be used in solution phase applications?
- Is there a SynPhase™ Lantern suitable for hydrophilic applications?
- Can SynPhase™ Lanterns be used in automated synthesizers?
- How does the cost of SynPhase™ Lanterns compare to resin(s)?