FAQs
Combinatorial Chemistry
- What are SynPhase™ Lanterns?
- What are the physical dimensions of SynPhase™ Lanterns?
- What is the fundamental difference between SynPhase™ Lanterns and Polystyrene Resins?
- Are there any special storage requirements with SynPhase™ Lanterns?
- What is the typical loading capacity of SynPhase™ Lanterns?
- What linkers are available with SynPhase™ Lanterns?
- How does the performance of SynPhase™ Lanterns compare to polystyrene resins?
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Does polystrene resin chemistry transfer directly to SynPhase™ Lanterns?
In direct comparisons between polystyrene resin and Lanterns, experimental chemistry protocols have been found to be fully transferable. In addition, kinetics have often proved to be faster on SynPhase Lanterns. The higher and more uniform reaction rates can be attributed to the structure of the SynPhase Lantern itself, which allows better diffusion of the reactive species inside the matrix due to the low level of cross-linking of the uniform 50µm thick polystyrene graft.
The improvements in reaction kinetics also apply to the kinetics of the washing step. Removal of excess reagents and side-products is very fast and economical. For example, removal of palladium salts (post-Suzuki coupling chemistry) is a straightforward procedure on Lanterns whereas on resin, long and tedious washes are required to ensure complete removal of salts.
A range of published chemistries utilizing linkers such as Rink, HMP, BAL and Trityl have been performed with SynPhase Lanterns and published as SynPhase Chemistry Notes. These syntheses were selected from peer-reviewed literature where the chemistry had been performed on polystyrene resin and led to "structurally interesting", non-peptidic organic compounds of molecular weight <500
- What solvents are compatible with SynPhase™ Lanterns? What are the swelling characteristics of SynPhase™ Lanterns in various solvents?
- What are the recommended volumes and concentrations of reagents for use with SynPhase™ Lanterns?
- What synthesis strategies can be used with SynPhase™ Lanterns?
- Can SynPhase™ Lanterns be used in solution phase applications?
- Is there a SynPhase™ Lantern suitable for hydrophilic applications?
- Can SynPhase™ Lanterns be used in automated synthesizers?
- How does the cost of SynPhase™ Lanterns compare to resin(s)?